AD-35 phosphate( AD35 phosphate | AD 35 phosphate )

Catalog No. M12150 CAS No. 1531586-64-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AD-35 phosphate
Note

Research use only, not for human use.
Brief Description

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.
Description

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.
In Vitro

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In Vivo

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Synonyms

AD35 phosphate | AD 35 phosphate
Pathway

Metabolic Enzyme/Protease
Target

AChE
Recptor

AChE
Research Area

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Indication

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CAS Number

1531586-64-7
Formula Weight

503.485
Molecular Formula

C24H27N3O3.H3O4P
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

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Chemical Name

6'-[2-[1-(Pyridin-2-ylmethyl)piperidin-4-yl]ethyl]spiro[cyclopropane-1,5'-[1,3]dioxolo[4,5-f]isoindol]-7'(6’H)-one phosphate

1. Li L, et al. J Alzheimers Dis. 2017;56(4):1403-1417.

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