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AD-35 phosphate

CAS No. 1531586-64-7

AD-35 phosphate ( AD35 phosphate;AD 35 phosphate )

Catalog No. M12150 CAS No. 1531586-64-7

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AD-35 phosphate
  • Note
    Research use only, not for human use.
  • Brief Description
    A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.
  • Description
    A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.
  • Synonyms
    AD35 phosphate;AD 35 phosphate
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    AChE
  • Recptor
    AChE
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1531586-64-7
  • Formula Weight
    503.49
  • Molecular Formula
    C24H27N3O3.H3O4P
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    ——
  • Chemical Name
    6'-[2-[1-(Pyridin-2-ylmethyl)piperidin-4-yl]ethyl]spiro[cyclopropane-1,5'-[1,3]dioxolo[4,5-f]isoindol]-7'(6’H)-one phosphate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li L, et al. J Alzheimers Dis. 2017;56(4):1403-1417.
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